Sculptra vs. Radiesse: Choosing the Right Biostimulator
Learn the difference between Sculptra and Radiesse biostimulators. Discover which collagen-boosting treatment is right for your skin goals.

Fernando
Marketing Manager
11/20/2025 ·
If you've been researching advanced anti-aging treatments in Vancouver, you have likely come across the term "biostimulator." Unlike traditional dermal fillers that simply add volume, biostimulators work by activating your body’s natural collagen and elastin production.
At The Vanity Lab, we offer the two leading biostimulators available today: Sculptra® and Radiesse®.
While both treatments are designed to restore structure and improve skin quality over time, they use different ingredients and deliver results in distinct ways. Understanding how each works can help you decide which approach best aligns with your skin goals.
What Are Biostimulators?
Biostimulators are injectable treatments that stimulate your body’s own regenerative processes. Rather than filling a wrinkle or hollow directly, they encourage collagen and elastin production, improving skin strength, firmness, and volume from within.
This makes them an ideal option for patients looking for long-term rejuvenation rather than a short-term cosmetic fix.
The Key Difference: Ingredients and Mechanism
The primary distinction between Sculptra and Radiesse lies in the active compound used to trigger collagen production:
- Sculptra® (Poly-L-Lactic Acid)
Sculptra is made from Poly-L-Lactic Acid (PLLA), a biocompatible material that has been used safely in medical sutures for decades.
Once injected, Sculptra creates a controlled inflammatory response in the skin. This process activates fibroblasts, the cells responsible for producing collagen. Over time, new collagen strands form, reinforcing the skin’s structural foundation and restoring volume gradually. - Radiesse® (Calcium Hydroxylapatite)
Radiesse contains Calcium Hydroxylapatite (CaHA) microspheres suspended in a gel carrier.
These microspheres act as a supportive framework beneath the skin. The gel provides immediate structure and volume, while the microspheres stimulate collagen and elastin production as the gel is naturally absorbed.
How the Results Differ: Immediate Structure vs. Gradual Renewal
Both Sculptra and Radiesse can deliver results that last up to two years, but the timeline and visual progression are different.
1. Immediate vs. Gradual
- Radiesse offers visible improvement right away due to its gel carrier. Patients often notice enhanced definition immediately, particularly in areas like the jawline or cheeks. Over time, your own collagen replaces the gel, maintaining the result.
- Sculptra requires more patience. It does not provide instant volume. Any fullness seen immediately after treatment is typically due to swelling and hydration. True results develop gradually over several months as collagen production increases.
2. Treatment Series and Aftercare
Both treatments are typically performed as a series of sessions, most often three treatments spaced several weeks apart.
Aftercare is similar for both and may include massage to ensure even product distribution. Patients are usually advised to massage the treated areas for 5 minutes, 5 times a day, for 5 days.
Choosing the Right Biostimulator
The best option depends on your goals, anatomy, and how quickly you want to see results.
Choose Radiesse If:
- You want immediate improvement with long-term collagen support
- You are defining areas such as the jawline or cheekbones
- You want to restore volume in the hands
Choose Sculptra If:
- You prefer a gradual, natural-looking transformation
- You are addressing widespread volume loss in the temples or cheeks
- You are interested in body contouring, such as hip dips
Ready to Build Your Collagen?
Both Sculptra and Radiesse are powerful tools for rebuilding collagen and restoring structure over time. Choosing the right biostimulator starts with a thorough consultation and a personalized plan.
Book your biostimulator consultation today
Call us: 604-699-1001
E-mail: info@thevanitylab.com



